February 18, 2026

E26 - Advances in Liver Cancer Treatment

12 minutes

E26 | 13 min | Latest | Publication Link

Podcast based on: Morishita, A.; Oura, K.; Tai, H.; Yano, R.; Nakahara, M.; Tadokoro, T.; Fujita, K.; Mimura, S.; Tani, J.; Tatsuta, M.; Himoto, T.; Kobara, H. Advances in the Therapeutic Landscape of Hepatocellular Carcinoma: Current Strategies and Future Perspectives. Cancers 2026, 18, 609. https://doi.org/10.3390/cancers18040609

Type: Review | Publication date: 12 February 2026

Summary: Hepatocellular carcinoma (HCC) arises mostly in chronically diseased livers, so clinicians must manage both an aggressive cancer and a fragile organ simultaneously. This review explains how modern HCC care has evolved into an integrated continuum: from prevention and surveillance to curative options such as resection, ablation, and transplantation, to refined locoregional therapy and immunotherapy-based systemic regimens. We highlight how treatment decisions are tailored according to tumor stage, liver function, portal hypertension, and frailty, and why preserving hepatic reserve is crucial to allow multiple lines of therapy. We also summarize emerging tools such as biomarkers, liquid biopsy, radiomics, and microbiome research that may support more precise treatment selection. Finally, we discuss special populations, safety considerations, and future strategies that combine innovative and traditional approaches to improve survival and quality of life for patients with HCC worldwide. This review aims to guide practical clinical decision-making.

Keywords: hepatocellular carcinoma; cirrhosis; surveillance; Barcelona Clinic Liver Cancer; transarterial chemoembolization; radioembolization; stereotactic body radiotherapy; immune checkpoint inhibitor; tyrosine kinase inhibitor; biomarkers

Disclaimer:

This podcast provides a synthetically generated voice summary and discussion of scientific publications. The views expressed do not represent the views of the original authors, journals, or publishers. This podcast uses AI-assisted summaries, so it may or may not introduce inaccuracies or omit important details. Listeners are strongly encouraged to consult the original publications or sources for full context and accuracy. This podcast is for educational and informational purposes only and does not constitute clinical advice, medical guidance, or recommendations. The creators of this podcast are not liable for any errors, omissions, or outcomes resulting from the use of the information provided.

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