January 07, 2026

E4 - Ewing Sarcoma Age Patterns

8 minutes

E4 | 9 min | Latest | Publication Link

Podcast based on: Ali, R.H.; Mohammed, E.M.A.; Ahmed, A.A.; Alsaber, A.R.; Al-Otaibi, H.S.; Abdulmoneim, S.A.K.; Hassan, A.; Almousawi, F.; Khalifa, N.; Ali, A.A.; Bahzad, S.; Alenezi, F.G.; AlNassar, M.; AlJassim, A. Age-Related Clinicopathologic Patterns in Ewing Sarcoma (FET::ETS Family): A Comparative Analysis of Pediatric and Adult Patients. Cancers 2025, 18, 133. https://doi.org/10.3390/cancers18010133

Type: Article | Publication date: 30 December 2025

Summary: Ewing sarcoma is a rare and aggressive cancer of bone and soft tissue that most often affects teenagers. Because it is uncommon and can arise in many different parts of the body, it can be difficult to recognize—particularly when it occurs outside the typical age range or in unusual anatomical sites. This challenge is especially relevant in regions where molecular diagnostic testing is relatively new or inconsistently available, which can complicate accurate diagnosis. In this study, we compared clinical, anatomical, pathological, molecular, treatment, and outcome features of Ewing sarcoma across three age groups: children (0–18 years), adolescents/young adults (19–39 years), and older adults (≥40 years). We identified clear age-related patterns, including a shift from predominantly bone tumors in younger patients to predominantly soft-tissue tumors in older adults. These insights can improve diagnostic accuracy, guide clinical decision-making, and strengthen regional understanding of this rare malignancy.

Keywords: Ewing sarcoma; FET-ETS; Ewing-like; pediatric oncology; old adults; extraskeletal; RNA sequencing

Disclaimer:

This podcast provides a synthetically generated voice summary and discussion of scientific publications. The views expressed do not represent the views of the original authors, journals, or publishers. This podcast uses AI-assisted summaries, so it may or may not introduce inaccuracies or omit important details. Listeners are strongly encouraged to consult the original publications or sources for full context and accuracy. This podcast is for educational and informational purposes only and does not constitute clinical advice, medical guidance, or recommendations. The creators of this podcast are not liable for any errors, omissions, or outcomes resulting from the use of the information provided.

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