I go through a number of tangles that have come up trying to translate cause prioritisation theory into practice at OpenPhil, some proposed patches, and remaining open questions. (Credit for most of these ideas goes to other people; I make attributions whenever I can.)

Source: Effective Altruism Global (video).

Effective Altruism is a social movement dedicated to finding ways to do the most good possible, whether through charitable donations, career choices, or volunteer projects. EA Global conferences are gatherings for EAs to meet. You can also listen to this talk along with its accompanying video on YouTube.