NIH researchers developed a four-dimensional brain map using a marmoset model to study the early stages of multiple sclerosis (MS). The study identified a new MRI signature that reveals brain regions at risk for MS damage before visible lesions appear. A key finding was the role of SERPINE1-expressing astrocytes in lesion development and repair, potentially influencing immune responses. This research offers insights into early MS disease activity and could guide the development of future treatments to slow or stop disease progression, and may provide implications for other brain injuries beyond MS. The marmoset model mimics human MS more closely than mice, allowing real-time tracking of lesion formation and providing a valuable resource for understanding MS pathology and identifying therapeutic targets. The researchers aim to expand their data by studying aged animals.

https://neurosciencenews.com/brain-map-ms-28445/

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