Question: Is whole food vitamin C superior to natural because it is part of a tyrosinase complex?

This is a question asked live during the June 16, 2023 AMA.Short Answer: Vitamin C is nearly ubiquitously distributed in plant tissues, and is never bound to any enzyme as a structural complex. Vitamin C promotes absorption of iron from plant foods, inhibits copper absorption, and de-loads copper from ceruloplasmin, which may play a role in distributing copper to tissues. Vitamin C is not capable of destroying ceruloplasmin. These functions follow directly from vitamin C as an electron donor and there is no evidence whatsoever that whole food vitamin C behaves differently in these respects than synthetic vitamin C. However, daily needs in most contexts are 2-400 milligrams of vitamin C per day, which is below the dose shown to potentially cause problems with copper. Getting this from whole foods or whole food supplements is better than using synthetic vitamin C because it avoids GMO corn and Chinese synthetics and provides a host of other beneficial constituents alongside the vitamin C.

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.

This snippet is from the June 16, 2023, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | June 16, 2023 AMA

Questions on hair trace mineral analysis, the real problem with seed oils, the supposed vitamin C tyrosinase complex, respiratory chain disorders, body composition, and more.

The questions include:

* How useful is hair trace mineral analysis (HTMA) for nutritional testing?

* What is the real issue with seed oils?

* Butyrate for Hashimoto’s? What else?

* What in the comprehensive nutritional screening is helping to interpret lactate/pyruvate and ketone ratios?

* Is the solution to a respiratory chain disorder to take Niagen?

* If I have high manganese on an HTMA, do I need to detox?

* Should CFS patients target reducing their serum BH4?

* What to do about low alkaline phosphatase?

* If my glucose spikes above 140, should I eat fiber and take ACV before the meal, eat cinnamon with the meal, chew slowly, and move for ten minutes after my meals?

* Difficulty getting Quest to do the lactate/pyruvate ratio correctly.

* Is 38 milligrams of niacinamide enough to rule out niacin deficiency as a cause of low NAD+?

* How does optimizing body composition help optimize energy metabolism? Can impaired energy metabolism make someone fatter?

* Is monounsaturated fat the best fat?

* Manganese followup.

* Do you need to stop taking biotin before a biotin test?

* What in "a bunch of supplements" flip the lactate/pyruvate ratio from high to low?

* NAD infusions, yay or nay?

* Why do I feel better after a warm shower, even better than after sunshine?

* Should I cut back on vitamin A if I have toxicity symptoms but cutting back makes me get sick?

* Do home blood drop tests have to be pricked at the finger?

* Is it true that my boyfriend was just born a night owl?

* How much eating out is too much?

* When measuring ketones, lactate, and glucose at home to optimize energy metabolism, what time of day should we take the measurements?Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Please Show This Post Some Love

Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.

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Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button:

Take a Look at the Store

* At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.

* For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.

* For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.

* For $10, you can purchase the Healing From COVID Vaccine Side Effects guide.

* For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit chrismasterjohnphd.substack.com/subscribe

Question: What Is the Real Issue With Seed Oils?

This is a question asked live during the June 16, 2023 AMA.Short Answer: The main issue with seed oils is that they present an oxidative liability. They do not acutely cause oxidative stress, but their polyunsaturated fatty acids (PUFAs) are more vulnerable than any other macronutrient to oxidative damage. Oxidative stress can increase because of nutrient deficiencies, toxins, infections, other sources of inflammation, alcohol, or smoking, and it will inevitably increase as a function of aging. As oxidative stress increases, more PUFAs in the tissues mean more damage. At least 0.6 milligrams of vitamin E should be gotten per gram of PUFA in the diet, but vitamin E cannot fully protect against PUFA, so their intake should be moderated to the very low levels needed, as obtained by eating fatty fish once or twice a week, eating eggs daily, and eating 4-8 ounces of liver per week. Additional secondary problems with them include residual solvents and heat damage prior to intake, but the main issue is that we do not want to increase our tissue PUFA content more than needed.

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.

This snippet is from the June 16, 2023, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | June 16, 2023 AMA

Questions on hair trace mineral analysis, the real problem with seed oils, the supposed vitamin C tyrosinase complex, respiratory chain disorders, body composition, and more.

The questions include:

* How useful is hair trace mineral analysis (HTMA) for nutritional testing?

* Vitamin C: Synthetic Vs. Natural

* Butyrate for Hashimoto’s? What else?

* What in the comprehensive nutritional screening is helping to interpret lactate/pyruvate and ketone ratios?

* Is the solution to a respiratory chain disorder to take Niagen?

* If I have high manganese on an HTMA, do I need to detox?

* Should CFS patients target reducing their serum BH4?

* What to do about low alkaline phosphatase?

* If my glucose spikes above 140, should I eat fiber and take ACV before the meal, eat cinnamon with the meal, chew slowly, and move for ten minutes after my meals?

* Difficulty getting Quest to do the lactate/pyruvate ratio correctly.

* Is 38 milligrams of niacinamide enough to rule out niacin deficiency as a cause of low NAD+?

* How does optimizing body composition help optimize energy metabolism? Can impaired energy metabolism make someone fatter?

* Is monounsaturated fat the best fat?

* Manganese followup.

* Do you need to stop taking biotin before a biotin test?

* What in "a bunch of supplements" flip the lactate/pyruvate ratio from high to low?

* NAD infusions, yay or nay?

* Why do I feel better after a warm shower, even better than after sunshine?

* Should I cut back on vitamin A if I have toxicity symptoms but cutting back makes me get sick?

* Do home blood drop tests have to be pricked at the finger?

* Is it true that my boyfriend was just born a night owl?

* How much eating out is too much?

* When measuring ketones, lactate, and glucose at home to optimize energy metabolism, what time of day should we take the measurements?Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Please Show This Post Some Love

Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.

Join the Next Live Q&A

Have a question for me? Ask it at the next Q&A! Learn more here.

Subscribe

Subscribe or upgrade your subscription here:

Subscribed

Join the Masterpass

Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button:

Take a Look at the Store

* At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.

* For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.

* For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.

* For $10, you can purchase the Healing From COVID Vaccine Side Effects guide.

* For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit chrismasterjohnphd.substack.com/subscribe

Question: How useful is hair trace mineral analysis (HTMA) for nutritional testing?

This is a question asked live during the June 16, 2023 AMA.Short Answer: Hair trace mineral analysis is included as an optional add-on in the comprehensive nutritional screening from Testing Nutritional Status: The Ultimate Cheat Sheet, because it can capture data for some ultra-trace minerals for which there are no better-validated tests, and it might capture a pattern that might not be picked up as quickly with blood work, such as a mineral transport issue. However, its utility is limited by the fact that hair mineral content is not well validated as a test for any specific mineral, is generally anti-validated when there is enough science on a mineral (such as zinc, where hair zinc does not go down in deficiency), and should not be used as a central piece of data without corroboration from other more well-validated tests, which exist for most of the nutrients.

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.

This snippet is from the June 16, 2023, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | June 16, 2023 AMA

Questions on hair trace mineral analysis, the real problem with seed oils, the supposed vitamin C tyrosinase complex, respiratory chain disorders, body composition, and more.

The questions include:

* What is the real issue with seed oils?

* Vitamin C: Synthetic Vs. Natural

* Butyrate for Hashimoto’s? What else?

* What in the comprehensive nutritional screening is helping to interpret lactate/pyruvate and ketone ratios?

* Is the solution to a respiratory chain disorder to take Niagen?

* If I have high manganese on an HTMA, do I need to detox?

* Should CFS patients target reducing their serum BH4?

* What to do about low alkaline phosphatase?

* If my glucose spikes above 140, should I eat fiber and take ACV before the meal, eat cinnamon with the meal, chew slowly, and move for ten minutes after my meals?

* Difficulty getting Quest to do the lactate/pyruvate ratio correctly.

* Is 38 milligrams of niacinamide enough to rule out niacin deficiency as a cause of low NAD+?

* How does optimizing body composition help optimize energy metabolism? Can impaired energy metabolism make someone fatter?

* Is monounsaturated fat the best fat?

* Manganese followup.

* Do you need to stop taking biotin before a biotin test?

* What in "a bunch of supplements" flip the lactate/pyruvate ratio from high to low?

* NAD infusions, yay or nay?

* Why do I feel better after a warm shower, even better than after sunshine?

* Should I cut back on vitamin A if I have toxicity symptoms but cutting back makes me get sick?

* Do home blood drop tests have to be pricked at the finger?

* Is it true that my boyfriend was just born a night owl?

* How much eating out is too much?

* When measuring ketones, lactate, and glucose at home to optimize energy metabolism, what time of day should we take the measurements?

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Please Show This Post Some Love

Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.

Join the Next Live Q&A

Have a question for me? Ask it at the next Q&A! Learn more here.

Subscribe

Subscribe or upgrade your subscription here:

Subscribed

Join the Masterpass

Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button:

Take a Look at the Store

* At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.

* For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.

* For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.

* For $10, you can purchase the Healing From COVID Vaccine Side Effects guide.

* For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit chrismasterjohnphd.substack.com/subscribe

Question: How do we find the root cause of an autoimmune condition? One example considered where the root cause is energy metabolism.

This is a question asked live during the May 13, 2023 AMA.Short Answer: Autoimmune conditions are likely driven by deficiencies of vitamins A and D, which contribute to post-infectious autoimmunity by compromising the rhythmic rise and fall of myeloid-derived suppressor cells (MDSCs), and to autoimmunity regardless of infections through impaired suppression of Th17 helper T cells. More broadly, infections and tissue damage are the most likely drivers of autoimmunity onset. However, energy metabolism governs everything through the second law of thermodynamics, which holds that energy must be used to prevent everything from randomly mixing, and this includes randomly mixing the immune defense against pathogens with immune attacks on the host. In this example, we discuss how a respiratory chain disorder would compromise absorption and distribution of zinc and compromise the oxidation of NADH to NAD+, and how both of these would interact with a genetic impairment in acetaldehyde dehydrogenase to prevent the activation of vitamin A to retinoic acid. Autoimmunity thus results as one of many symptoms of vitamin A deficiency driven not by lack of vitamin A, but rather by impaired activation of vitamin A, secondary to impaired energy metabolism. 

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.

This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | May 13, 2023 AMA

Questions on NAC, biofilms, vitamin C and brain fog, energy metabolism driving autoimmune disorders, milk, methylene blue, and more.

* Can NAC hurt your gut health?

* Why Would Vitamin C cause muscle pain, joint pain, and brain fog?

* GLA to lower hydroxyhaemopyrrolin-2-one?

* When would I use the StrateGene and Genova Methylation Panel for nutritional testing?

* Energy metabolism as a root cause of gut issues?

* Nutrition for skin healing?

* Nutrition for hypnic jerks?

* Suggestions for snoring or sleep apnea?

* Nutrition to protect against restaurant meals?

* What is the cause of crusty eyes in the morning?

* What causes brain fog?

* How much oxalate should one eat each day?

* Should I be concerned about low alkaline phosphatase?

* What nutrients give tall children to short parents?

* Energy metabolism impairment mimicking Wilson's disease.

* Can taking digestive enzymes reduce our own production?

* Rapid-fire response to non-winners from the question contest.

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Please Show This Post Some Love

Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.

Join the Next Live Q&A

Have a question for me? Ask it at the next Q&A! Learn more here.

Subscribe

Subscribe or upgrade your subscription here:

Join the Masterpass

Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button:

Take a Look at the Store

* At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.

* For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.

* For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.

* For $10, you can purchase the Healing From COVID Vaccine Side Effects guide.

* For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit chrismasterjohnphd.substack.com/subscribe

Question: Why Would Vitamin C Cause Joint Pain, Muscle Pain, and Brain Fog?

This is a question asked live during the May 13, 2023 AMA.Short Answer: Acutely, vitamin C would likely cause these effects by generating oxalate, which could cause crystals that lead to muscle and joint pain, and could cut energy metabolism in half, leading to brain fog. This vulnerability could result from deficiencies of any of the B vitamins, any of the electrolytes, or of iron, copper, or sulfur; from diabetes, low adrenals, or hypothyroidism; or from any of the hundreds of genetic defects in energy metabolism, only one of which is glucose 6-phosphate dehydrogenase deficiency; or any one of a huge number of toxins that impair energy metabolism. Chronically, vitamin C may increase the harms of iron overload or contribute to copper deficiency. The main ways to manage these latter issues are to take vitamin C away from meals, to maintain good copper status through proper dietary intake, and to treat iron overload with phlebotomy.

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.

This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | May 13, 2023 AMA

Questions on NAC, biofilms, vitamin C and brain fog, energy metabolism driving autoimmune disorders, milk, methylene blue, and more.

* Can NAC hurt your gut health?

* How do we find the root cause of an autoimmune condition? One example considered.

* GLA to lower hydroxyhaemopyrrolin-2-one?

* When would I use the StrateGene and Genova Methylation Panel for nutritional testing?

* Energy metabolism as a root cause of gut issues?

* Nutrition for skin healing?

* Nutrition for hypnic jerks?

* Suggestions for snoring or sleep apnea?

* Nutrition to protect against restaurant meals?

* What is the cause of crusty eyes in the morning?

* What causes brain fog?

* How much oxalate should one eat each day?

* Should I be concerned about low alkaline phosphatase?

* What nutrients give tall children to short parents?

* Energy metabolism impairment mimicking Wilson's disease.

* Can taking digestive enzymes reduce our own production?

* Rapid-fire response to non-winners from the question contest.

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Please Show This Post Some Love

Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.

Join the Next Live Q&A

Have a question for me? Ask it at the next Q&A! Learn more here.

Subscribe

Subscribe or upgrade your subscription here:

Join the Masterpass

Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button:

Take a Look at the Store

* At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.

* For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.

* For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.

* For $10, you can purchase the Healing From COVID Vaccine Side Effects guide.

* For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit chrismasterjohnphd.substack.com/subscribe

Question: Can NAC Hurt Gut Health When Used to Disrupt Biofilms?

This is a question asked live during the May 13, 2023 AMA.Short Answer: N-acetylcysteine or NAC can be used at a dose of 600 to 2,400 milligrams per day for 5-10 days to disrupt biofilms and make it easier for antimicrobials to kill bacteria. Animal studies suggest that acute doses up to 6 grams do not deplete mucus or cause ulceration, but that an acute dose of 17.5 grams can deplete mucus and cause ulcers within two hours. Human studies suggest that 10 grams per day can be used for 24 weeks with fewer than 1 in 6 people complaining of gastrointestinal side effects. Yet, chronic use of NAC will thin the mucus, disrupt the biofilms used by normal healthy microbiota, and possibly deliver excessive sulfur to certain components of the microbiome. Therefore, I would not use it except for specific, targeted reasons, and I would not use it at a dose higher than needed or for a duration longer than needed.

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.

This snippet is from the May 13, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | May 13, 2023 AMA

Questions on NAC, biofilms, vitamin C and brain fog, energy metabolism driving autoimmune disorders, milk, methylene blue, and more.

* Why Would Vitamin C cause muscle pain, joint pain, and brain fog?

* How do we find the root cause of an autoimmune condition? One example considered.

* GLA to lower hydroxyhaemopyrrolin-2-one?

* When would I use the StrateGene and Genova Methylation Panel for nutritional testing?

* Energy metabolism as a root cause of gut issues?

* Nutrition for skin healing?

* Nutrition for hypnic jerks?

* Suggestions for snoring or sleep apnea?

* Nutrition to protect against restaurant meals?

* What is the cause of crusty eyes in the morning?

* What causes brain fog?

* How much oxalate should one eat each day?

* Should I be concerned about low alkaline phosphatase?

* What nutrients give tall children to short parents?

* Energy metabolism impairment mimicking Wilson's disease.

* Can taking digestive enzymes reduce our own production?

* Rapid-fire response to non-winners from the question contest.

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Please Show This Post Some Love

Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.

Join the Next Live Q&A

Have a question for me? Ask it at the next Q&A! Learn more here.

Subscribe

Subscribe or upgrade your subscription here:

Join the Masterpass

Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button:

Take a Look at the Store

* At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.

* For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.

* For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.

* For $10, you can purchase the Healing From COVID Vaccine Side Effects guide.

* For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit chrismasterjohnphd.substack.com/subscribe

Question: How can I protect against oxalates?

This is a question asked live during the April 12, 2023 AMA.Short Answer: Getting 300-400 mg calcium between food and supplements at each meal will minimize oxalate absorption. Maintaining postprandial urine pH in the 6.4-6.8 range by getting 3-5 grams of potassium per day from food or from organic acid salts such as potassium citrate will prevent its crystallization in the kidney. Reducing dietary oxalate will prevent any possible damage in the gut.

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.

This snippet is from the April 12, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | April 12, 2023 AMA

All things heart disease, and on blood sugar, nutritional testing, oxalates, and more.

The questions include:

* What Causes Hypercholesterolemia and Does It Matter?

* Why Should Postprandial Glucose Be Kept Under 140 mg/dL?

* How to Reverse Coronary Calcification?

* How to do a comprehensive nutritional screening

* How long after eating improperly cooked egg whites should I wait to take biotin?

* Is the extrusion process as harmful as some claim?

* How long can one fast before micronutrient deficiencies become an issue?

* Do B vitamins compete with each other for absorption?

* Why is thirst a symptom of diabetes?

* Do I agree with Peter Attia that ApoB should be driven as low as pharmacologically possible?

* During a fast, does the body break down muscle?

* How do you rest and refeed your brain?

* Why would someone have high RBC magnesium but low serum magnesium?

* GLA deficiency?

* Should we eat for our ethnicity?

* How convincing are polyphenol studies?

* Can coronary calcium be driven by oxalate?

* Citrulline for vasodilation

* How to reduce catabolism

* Rapid-fire run-through of orphaned questions from the submission contest, including a detailed look at Nadia’s thyroid numbers

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Please Show This Post Some Love

Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.

Join the Next Live Q&A

Have a question for me? Ask it at the next Q&A! Learn more here.

Subscribe

Subscribe or upgrade your subscription here:

Subscribed

Join the Masterpass

Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button:

Take a Look at the Store

* At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.

* For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.

* For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.

* For $10, you can purchase the Healing From COVID Vaccine Side Effects guide.

* For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit chrismasterjohnphd.substack.com/subscribe

Question: Why should postprandial blood glucose be kept under 140 milligrams per deciliter?

This is a question asked live during the April 12, 2023 AMA.Short Answer: When blood glucose rises above 140 mg/dL, this is the approximate point at which it spills into the polyol pathway at a greater-than-normal rate, which represents a suboptimal state of metabolism that is likely to hurt antioxidant status and compromise detoxification pathways as well as the recycling of vitamin K and folate. It must be kept in mind that a healthy person will adapt to glycemic loads they consume regularly. Thus, a one-time spike above 140 mg/dL should never be used to conclude anything whatsoever. Only repeated spikes above this level with repeated consumption of the same glycemic load over several days to several weeks should be used as a cause for concern.

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.

This snippet is from the April 12, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | April 12, 2023 AMA

All things heart disease, and on blood sugar, nutritional testing, oxalates, and more.

The questions include:

* What Causes Hypercholesterolemia and Does It Matter?

* How to Reverse Coronary Calcification?

* How to do a comprehensive nutritional screening

* How can I protect against oxalates?

* How long after eating improperly cooked egg whites should I wait to take biotin?

* Is the extrusion process as harmful as some claim?

* How long can one fast before micronutrient deficiencies become an issue?

* Do B vitamins compete with each other for absorption?

* Why is thirst a symptom of diabetes?

* Do I agree with Peter Attia that ApoB should be driven as low as pharmacologically possible?

* During a fast, does the body break down muscle?

* How do you rest and refeed your brain?

* Why would someone have high RBC magnesium but low serum magnesium?

* GLA deficiency?

* Should we eat for our ethnicity?

* How convincing are polyphenol studies?

* Can coronary calcium be driven by oxalate?

* Citrulline for vasodilation

* How to reduce catabolism

* Rapid-fire run-through of orphaned questions from the submission contest, including a detailed look at Nadia’s thyroid numbers

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

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Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.

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Take a Look at the Store

* At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.

* For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.

* For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.

* For $10, you can purchase the Healing From COVID Vaccine Side Effects guide.

* For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit chrismasterjohnphd.substack.com/subscribe

Question: What is the relationship between copper and estrogen?

This is a question asked live during the March 14, 2023 AMA.

Short Answer: Estrogen moves copper from the mother’s bloodstream to the fetus during pregnancy. Its action at the intestines is poorly understood but I believe estrogen and progesterone interact to promote intestinal copper absorption. Maintaining pregnancy-level hormones while not pregnant poses a risk of promoting too much absorption of copper from food without transferring it to a growing baby. Copper status should be monitored when using supplemental hormones to avoid copper toxicity.

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.

This snippet is from the March 14, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | March 14, 2023

Hair loss, erythritol, estrogen, copper, and more.

The questions include:

* How to slow or reverse graying of hair?

* What about that new erythritol study?

* Can nicotinamide riboside cause hemolytic anemia in someone with G6PDH deficiency?

* Why is citric acid alkalinizing?

* If I switch my vitamin E to tocotrienols, am I missing anything?

* Vitamin A deficiency and toxicity symptoms at the same time?

* Vitamin A in pregnancy

* How long should I wait to measure whole blood riboflavin after making a change to my supplement?

* How to stack supplements for blood pressure?

* Rejuvant calcium alpha-ketoglutarate for anti-aging?

* Are dietary AGEs a problem?

* Is it safe to keep taking high-dose zinc?

* What’s the best way to get phosphorus?

* Weight loss question.

* How to eat to 80% full

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Please Show This Post Some Love

Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.

Join the Next Live Q&A

Have a question for me? Ask it at the next Q&A! Learn more here.

Subscribe

Subscribe or upgrade your subscription here:

Subscribed

Join the Masterpass

Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button:

Take a Look at the Store

* At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.

* For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.

* For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.

* For $10, you can purchase the Healing From COVID Vaccine Side Effects guide.

* For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit chrismasterjohnphd.substack.com/subscribe

Question: How to slow greying of hairs and potentially reverse it?This is a question asked live during the March 14, 2023 AMA.Short Answer: What works for any given individual will likely be to find the weakest link and fix it, from among the following systems: the signaling of energy abundance (body fat, insulin sensitivity, thyroid hormone, adequate protein, individualized meeting of carbohydrate needs, good management of psychosocial stress, supporting neuroendocrine signaling with copper, vitamin C, zinc, and glycine, and supporting thyroid function with iodine and selenium); the biochemical infrastructure of energy production (all the B vitamins, iron, copper, sulfur, magnesium, potassium, and managing genetic idiosyncrasies impacting energy metabolism), and antioxidant protection (protein, vitamin C, vitamin E, zinc, copper, selenium, iron, and manganese).

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up. Learn more about the Masterpass here.

This snippet is from the March 14, 2023 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

Ask Me Anything | March 14, 2023

Hair loss, erythritol, estrogen, copper, and more.

The questions include:

* What about that new erythritol study?

* What is the relationship between copper and estrogen?

* Can nicotinamide riboside cause hemolytic anemia in someone with G6PDH deficiency?

* Why is citric acid alkalinizing?

* If I switch my vitamin E to tocotrienols, am I missing anything?

* Vitamin A deficiency and toxicity symptoms at the same time?

* Vitamin A in pregnancy

* How long should I wait to measure whole blood riboflavin after making a change to my supplement?

* How to stack supplements for blood pressure?

* Rejuvant calcium alpha-ketoglutarate for anti-aging?

* Are dietary AGEs a problem?

* Is it safe to keep taking high-dose zinc?

* What’s the best way to get phosphorus?

* Weight loss question.

* How to eat to 80% full

Disclaimer

I am not a medical doctor and this is not medical advice. My goal is to empower you with information. Please make all health decisions yourself, consulting sources you trust, including a caring health care professional.

Please Show This Post Some Love

Let me know what you think in the comments! And please like the post if you found it valuable, and share the post with others if you believe they too would find it valuable.

Join the Next Live Q&A

Have a question for me? Ask it at the next Q&A! Learn more here.

Subscribe

Subscribe or upgrade your subscription here:

Subscribed

Join the Masterpass

Masterpass members get access to premium content (preview the premium posts here), all my ebook guides for free (see the collection of ebook guides here), monthly live Q&A sessions (see when the next session is here), all my courses for free (see the collection here), and exclusive access to massive discounts (see the specific discounts available by clicking here). Upgrade your subscription to include Masterpass membership with this button:

Take a Look at the Store

* At no extra cost to you, please consider buying products from one of my popular affiliates using these links: Paleovalley, Magic Spoon breakfast cereal, LMNT, Seeking Health, Ancestral Supplements. Find more affiliates here.

* For $2.99, you can purchase The Vitamins and Minerals 101 Cliff Notes, a bullet point summary of all the most important things I’ve learned in over 15 years of studying nutrition science.

* For $10, you can purchase The Food and Supplement Guide for the Coronavirus, my protocol for prevention and for what to do if you get sick.

* For $10, you can purchase the Healing From COVID Vaccine Side Effects guide.

* For $29.99, you can purchase a copy of my ebook, Testing Nutritional Status: The Ultimate Cheat Sheet, my complete system for managing your nutritional status using dietary analysis, a survey of just under 200 signs and symptoms, and a comprehensive guide to proper interpretation of labwork.

This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit chrismasterjohnphd.substack.com/subscribe