Rising temperatures and ecosystem disruption are reshaping the global landscape of infectious disease. Computational biologist Dr Rory Gibb joins Professor Philip Schofield to discuss how climate change and social inequality are fuelling increases in mosquito-borne illnesses like dengue fever and West Nile virus. From cutting-edge vaccines to rethinking urban design, Dr Gibb explains why tackling infectious disease requires urgent action; especially for the world’s most vulnerable communities.