HOPA Now is the official podcast of the Hematology/Oncology/Pharmacy Association, an organization dedicated to supporting pharmacy practitioners and promoting the advancement of Hematology/Oncology/Pharmacy to optimize the care of individuals impacted by cancer.

 

These educational podcasts are part of our BCOP Preparatory and Recertification Course, which is designed to prepare oncology pharmacists preparing to sit for the BCOP Certification Exam, as well as meet the BPS requirement to complete a BCOP Preparatory/Recertification Review Course.

 

In this episode of HOPA Now, Dr. Jennifer Godden addresses the top ten clinical pearls of molecular pathways and pharmacogenomics with the goal of ensuring that oncology pharmacists have a strong understanding of the key concepts related to oncology precision medicine, including tumor genomic test processes and test results, and to make accurate resulting treatment recommendations. Topics covered include classifications of cancers and characteristics of genetic mutations, treatment implications and gene alteration implications, signal transduction pathways, and the impact of semantic and germline alterations on treatment selections.

 

In this episode you will learn:

 

Molecular Pathways and Pharmacogenomics

• Classification of cancers and characteristics of genetic mutations as the cause of cancer
• Prognostic and predictive tumor molecular profiling processes and standards
• Functional and clinical impacts of alterations
• Treatment implications and decisions based on various gene alteration implications and their functions
• The two major signal transduction pathways that facilitate signaling from the extracellular domain to the nucleus
• Homologous recombination deficiencies and mismatch repairs
• How semantic and germline alterations in cancer genes can impact treatment selection and medication response

 

Mentioned in This Episode:

HOPA

 

Quotes:

“The application of molecular pathways and the treatment of oncology patients is expanding at a rapid pace.” — Dr. Jennifer Godden

 

“Cancer is a process that develops as a result of dysregulated pathways.” — Dr. Jennifer Godden

 

“It is important to recognize that a VUS should not routinely be used as part of treatment decision making.” — Dr. Jennifer Godden

 

“It is becoming increasingly important for oncology pharmacists to understand molecular pathways and pharmacogenomics.” — Dr. Jennifer Godden