A growing body of evidence demonstrates that improvements in the status of women and girls also drive the prosperity and security of families, communities, and nations. In recent years the US government has incorporated gender equality as a metric of policy development and program investment of its domestic and foreign policies. Yet despite many indicators of progress for women and girls everywhere more work remains, and strong collaborations are still needed in areas regarding women’s economic and political leadership, eliminating violence against women and girls, and supporting women-owned businesses and entrepreneurs. As the US prepares for new governance what would a change in leadership mean for women’s rights, domestically and internationally? And how can we best continue to provide US leadership to women’s issues in the next twenty years?