The National Cancer Institute has established a third Cancer Screening Research Network that will leverage emerging technologies and develop clinical trials that could lead to earlier detection of different types of cancer. Multi-cancer detection tests are showing a great deal of promise when it comes to screening for certain cancers that could result in a more timely diagnosis and treatment which in turn reduces the number of cancer deaths.  Dr. Lori Minasian, deputy director for the Division of Cancer Prevention at NCI, discusses how these tests fit into President Biden's Cancer Moonshot initiative, what the challenges around the tests are and more details about a new pilot study coming up in 2024.