EMS A to Z: TXA

Show Notes:

From your hosts, Dr. Josh Gaither, Dr. Amber Rice, and Dr. Rachel Munn

 

What is TXA?

TXA is the abbreviation for tranexamic acid; a lysine derivative medication which acts to displace plasminogen from fibrin and inhibit fibrinolysis

In plain language, this means that it prevents the breakdown of blood clots that the body has already formed

How is TXA administered?  

The standard dose is 1g over 10 minutes as slow IV push or in 100mL of saline

Faster administration reportedly may cause hypotension (which is bad for our already hypotensive trauma patients)

Potential Indications:  

Traumatic injury with hypotension or shock index > 1 (HR / BP) within 3 hours of injury

Relevant trials: 

MATTERS

CRASH2

STAAMP

Postpartum hemorrhage

WOMAN trial

TBI

CRASH3

Why is this relevant?

TXA was recently added to the scope of practice for paramedics in Arizona, so you may see this added to your guidelines / protocols and drug box