This "Colorectal Surgery Review" episode provides a deep dive into the rapidly evolving field of advanced endoscopy, framing it as a new surgical frontier called "endoluminal surgery." The discussion is aimed at colorectal surgeons and trainees, highlighting critical techniques, evolving evidence, and key nuances for board exams and clinical practice.

Key topics covered in the episode include:

• Historical Context and Evolution: The episode begins by drawing a parallel between the initial skepticism surrounding the adoption of colonoscopy in the 1970s and the current challenges and learning curves associated with advanced techniques like Endoscopic Submucosal Dissection (ESD).

• Polypectomy Techniques: The discussion covers the progression of polypectomy methods:

  • Forceps: It notes that while useful for small polyps, hot biopsy forceps are now recommended against by major guidelines due to tissue damage and a higher risk of delayed bleeding compared to cold techniques.

  • Cold vs. Hot Snare: There has been a significant shift towards using cold snare polypectomy for many smaller polyps (<10mm), as it has a lower risk of complications like delayed bleeding and perforation while achieving equivalent complete resection rates.

  • EMR (Endoscopic Mucosal Resection): This "lift and cut" technique is used for larger, flat lesions. It involves a submucosal injection to create a safety cushion before removing the polyp, often in a piecemeal fashion. While effective, this can lead to higher recurrence rates.

  • ESD (Endoscopic Submucosal Dissection): This is the most advanced technique, allowing for the removal of very large lesions in a single piece ("on-block"). This provides the best possible specimen for pathologists to assess for cancer, offering a potentially curative, organ-sparing option for select patients and avoiding major surgery. However, it is technically demanding with a significant learning curve and higher risks.

• Adjunctive Tools and Complication Management:

  • Endoscopic Clips: The podcast emphasizes a major practice change: routine prophylactic clipping after polypectomy is no longer recommended. However, selective clipping for high-risk lesions (e.g., >20mm, especially in the proximal colon) has been shown to reduce delayed bleeding.

  • New Technologies: The episode highlights tools that are transforming what is possible, including endoscopic suturing devices for closing large defects or perforations and stabilization platforms (like the double balloon system) that create a more stable environment for complex work inside the colon.

• Advanced Applications: The discussion also covers the use of self-expanding metal stents for palliating or as a "bridge to surgery" in malignant large bowel obstructions, as well as their off-label use for managing contained anastomotic leaks.

The central theme is that the role of the colorectal surgeon is expanding, requiring advanced endoscopic skills to manage complex polyps and conditions that previously would have required open or laparoscopic surgery.