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Wide release date: October 28, 2025.

Episode Summary: A reframe of biology as energy flow through resistance rather than mere molecular machinery, introducing the Energy Resistance Principle (ERP): life requires a Goldilocks balance of electron flow from food to oxygen via mitochondria; too much or too little resistance drives aging, disease, and death. Explain mitochondria as energy transformers, link ERP to insulin resistance, psychiatric disorders, and healing, and explore health as a dynamic field-like state optimized by flux modulation.

About the guest: Nirosha Murugan, PhD is a biophysicist studying how physical signals pattern biology to decode and reprogram health; Martin Picard, PhD is a mitochondrial psychobiologist at Columbia University, exploring how mitochondrial energy dynamics connect to human experiences, health, and healing. They collaborate on biophotons, light emission, and multi-scale energy signaling.

Discussion Points:

* Mitochondria transform electrons from food into versatile electricity via proton gradients.

* Energy Resistance Principle: transformation needs resistance; chronic high resistance causes dissipative heat, damage, aging.

* GDF15 cytokine signals mitochondrial stress to brain, triggering energy conservation/mobilization.

* Insulin resistance: adaptive defense against electron overload, reversible by fasting/exercise.

* Psychiatric illness: excess brain energy resistance; exercise, keto, psychedelics redistribute flux.

* Health: dynamic optimization of energy resistance, not absence of disease.

* Healing: daily recovery from micro-damage via balanced resistance.

* Future: energy-based diagnostics/therapies (light, TMS) over molecule-only drugs.

Reference Paper: The energy resistance principle

Related Episode:

* M&M 70: Mitochondria, Aging, Cellular Energy, Metabolism, Gray Hair Reversal & Brain-Body Communication | Martin Picard

*Not medical advice.

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* Episode transcript below.

Episode Chapters:

00:00:00 Intro

00:01:28 Guest Introductions

00:03:01 Collaboration at Columbia

00:04:56 Physics vs Stamp Collecting in Biology

00:10:47 Cadaver vs Living Organism

00:13:25 Energy Flow & Mitochondria Basics

00:19:05 Energy Resistance Principle Explained

00:26:44 ERP Goldilocks Zone & Aging

00:31:59 Flow Drives Metabolism

00:36:06 Dissipative Heat & Damage

00:39:00 Allometric Scaling & Lifespan

00:46:52 Mitochondrial Disease & Short Stature

01:19:59 GDF15 as Energy Stress Signal

01:29:57 Health & Healing via ERP

01:36:44 Intrinsic vs Realized Health

01:37:03 Insulin Resistance Reframed

01:43:54 Psychiatric Illness & Energy Resistance

01:53:51 Cancer as Chronic Resistance Adaptation

01:56:16 Electron Flow as Élan Vital

02:05:59 Closing Thoughts

Full AI-generated transcript below. Beware of typos & mistranslations!