thegreengage exploring the hidden connections between nature; mind, and science.

Ep. 10/44 — How Psychedelics Interact with the Serotonin System


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This episode is for educational purposes only. It is intended for mature audiences and explores scientific, historical, and cultural perspectives on psychoactive substances. Nothing in this content should be interpreted as medical advice or encouragement for illegal activity. Viewers are responsible for knowing and following their local laws. If you or someone you know is struggling with substance use or mental health, please seek support from a qualified healthcare provider.

Psychedelics don’t invent new worlds.They rearrange the tuning.And the key they use is serotonin.

In this episode, we follow the thread from simple biology to altered states of mind. Serotonin receptors, especially the mysterious 5-HT2A, act as gateways, not just for mood, but for the patterns that structure thought and self. When psychedelics enter the picture, these gateways open wider than usual, letting the current of consciousness flow in unexpected directions.

🔎 In this episode, we explore:

* How psychedelics mimic serotonin yet bend it toward visionary states

* The role of the 5-HT2A receptor as a portal of perception

* Why “disruption” of normal brain networks can feel like both chaos and revelation

* How dopamine’s reward and motivation circuits intersect with psychedelic states

* How ancient rituals intuited these effects long before neuroscience named them

Serotonin is the tuning fork.Psychedelics strike it with a different hand.And the resonance is what we call the psychedelic experience.



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thegreengage exploring the hidden connections between nature; mind, and science.By Green Gage exploring Cannabis, Psilocybin, and Ayahuasca