Heart disease is the leading cause of death in men and women alike, but the symptoms, causes, and outcomes differ among the sexes. Heart disease is a catch-all for many cardiovascular conditions, so for this episode, we are focusing on small vessel disease. Women tend to get blockages in the small vessels, whereas men have plaque build-up in their large arteries. Cardiologists Dr. Janet Wei of the Barbara Streisand Women's Heart Center at the Cedars-Sinai Smidt Heart Institute and Dr. Giulia Sheftel of Newton-Wellesley Hospital discuss how these blockages happen, Yentl Syndrome, and the interplay of estrogen and heart health.