The Colts have a shot at primetime redemption as they take on the 49ers Sunday night. Mike Chappell, Dave Griffiths and Joe Hopkins begin the show with some heavy news that includes major injuries to important players. The guys then check out the injury reports for this week's matchup (28:43), break down this 49ers team (37:49), discuss keys to the game (45:25) and make predictions (55:49).