Guillain–Barré Syndrome (GBS) is a rare but serious autoimmune disorder that can lead to rapid paralysis, respiratory failure, and even death if not recognized early. In this episode, we break down everything you need to know about GBS — from the underlying pathophysiology and clinical presentation, to the classic finding of albuminocytologic dissociation in the CSF, and the stepwise approach to diagnosis and treatment in the ICU.