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Ep 46-Don't Die: Bryan Johnson and Longevity Science
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A cookie-fueled cold open gives way to one of the thorniest questions in modern medicine: are we getting healthier, or just better at making numbers look good? Using Brian Johnson’s “Blueprint” as a case study, we unpack the science behind epigenetic clocks, the appeal of tight control, and the lesson medicine keeps relearning—lowering a risky marker isn’t the same as improving a life. We trace hard-won examples from ICU glucose control to HRT and anti-arrhythmics, then map that history onto today’s longevity culture, where proxies move fast and outcomes arrive slow.
Enjoy the ride, laugh at the holiday detours, and leave with a pragmatic checklist: sleep on purpose, move daily, eat simply, and be skeptical when a perfect metric is sold as a cure. If this resonated, follow the show, share it with a friend, and leave a quick review—your support helps us keep the conversation honest and useful.
Resources:
- Steve Horvath’s original epigenetic clock (2013, Genome Biology)
- National Law Review+1
- BryanJohnson.com
- GrimAge and PhenoAge models (Aging, Nature Communications)
- DunedinPACE (eLife, 2022)
- Home | CALERIE
- American Federation for Aging Research+1
- The Documentary “Don’t Die: The Man Who Wants to Live Forever” on Netflix
Support the show
Don't miss a (heart) beat! Check out our Instagram @doctoringthetruthpodcast and email us your Medical Mishaps at [email protected]. Join us on Facebook at Doctoring the Truth, and TikTok @doctoring the truth. Don't forget to download, rate, and review so we can keep bringing you more exciting content each week!
Stay safe, and stay suspicious...trust, after all, is a delicate thing!
Don't forget to check out these fantastic discounts using promo code STAYSUSPICIOUS from our sponsors at:
*thecuminclub.com for 30% off
*https://strongcoffeecompany.com/discount/STAYSUSPICIOUS for 20% off
*www.handful.com for 30% off
*www.standshoes.com for 15% off
*www.oldglory.com for 15% off
*www.getcheeky.com for 30% off
*https://mollybz.com for 10% off
*www.RSRVCollective.com for 30% off
*klearprotein.com for 20% off
*www.torrain.org for 15% off
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By Jenne Tunnell and Amanda HouseSend us a text
A cookie-fueled cold open gives way to one of the thorniest questions in modern medicine: are we getting healthier, or just better at making numbers look good? Using Brian Johnson’s “Blueprint” as a case study, we unpack the science behind epigenetic clocks, the appeal of tight control, and the lesson medicine keeps relearning—lowering a risky marker isn’t the same as improving a life. We trace hard-won examples from ICU glucose control to HRT and anti-arrhythmics, then map that history onto today’s longevity culture, where proxies move fast and outcomes arrive slow.
Enjoy the ride, laugh at the holiday detours, and leave with a pragmatic checklist: sleep on purpose, move daily, eat simply, and be skeptical when a perfect metric is sold as a cure. If this resonated, follow the show, share it with a friend, and leave a quick review—your support helps us keep the conversation honest and useful.
Resources:
- Steve Horvath’s original epigenetic clock (2013, Genome Biology)
- National Law Review+1
- BryanJohnson.com
- GrimAge and PhenoAge models (Aging, Nature Communications)
- DunedinPACE (eLife, 2022)
- Home | CALERIE
- American Federation for Aging Research+1
- The Documentary “Don’t Die: The Man Who Wants to Live Forever” on Netflix
Support the show
Don't miss a (heart) beat! Check out our Instagram @doctoringthetruthpodcast and email us your Medical Mishaps at [email protected]. Join us on Facebook at Doctoring the Truth, and TikTok @doctoring the truth. Don't forget to download, rate, and review so we can keep bringing you more exciting content each week!
Stay safe, and stay suspicious...trust, after all, is a delicate thing!
Don't forget to check out these fantastic discounts using promo code STAYSUSPICIOUS from our sponsors at:
*thecuminclub.com for 30% off
*https://strongcoffeecompany.com/discount/STAYSUSPICIOUS for 20% off
*www.handful.com for 30% off
*www.standshoes.com for 15% off
*www.oldglory.com for 15% off
*www.getcheeky.com for 30% off
*https://mollybz.com for 10% off
*www.RSRVCollective.com for 30% off
*klearprotein.com for 20% off
*www.torrain.org for 15% off