Dr. Ron explains why persistent exhaustion is often a bioenergetic problem linked to chronic inflammation and mitochondrial dysfunction, not just stress or age. He connects how oxidized polyunsaturated fats (especially adulterated linoleic acid from processed seed oils) damage mitochondrial membranes, reduce ATP production, and drive the fatigue epidemic.

The episode also covers why routine lab tests can miss mitochondrial strain, which markers may suggest metabolic stress, and practical approaches to restore metabolic flexibility, lower inflammation, and protect mitochondrial health.