In this episode of Psychopharmacology Today, Dr. Daubney Boland offers a practical and compassionate overview of gender-affirming care, emphasizing the critical role prescribing psychologists play in creating inclusive, respectful, and medically informed treatment environments for transgender and nonbinary patients. Drawing on clinical experience and case studies, she explores how affirming language, accurate pronoun use, and culturally competent systems reduce barriers to care, while delayed or withheld treatment can intensify depression, dysphoria, self-harm, and other mental health concerns. Dr. Boland also reviews key psychopharmacology considerations, including hormone therapy risks, informed consent, fertility counseling, and monitoring issues such as testosterone-related polycythemia, highlighting the importance of interdisciplinary collaboration and individualized, patient-centered decision-making in ethical gender-affirming practice.