Host Felix Boecker, MD cuts through the hype to clarify which supplements actually support healing. Drawing on guideline highlights and clinical data, he explains why protein is the cornerstone—with strongest evidence for arginine and glutamine (and situational HMB)—especially in malnourished or high-risk patients. He compares collagen powders vs. whole-protein intake, reviews where vitamins C, D, and zinc may help only when a deficiency is present, and why routine vitamin A/E use isn’t supported. He also addresses oral hyaluronic acid (skip it) and why branded mixes like Juven® don’t clearly outperform standard nutrition. Practical takeaways: prioritize high-protein nutrition, consider arginine-focused ONS for stage ≥2 pressure injuries, and test before you dose for micronutrients. A concise, evidence-aware guide for busy wound-care clinicians.