Chagas disease, also known as American trypanosomiasis, is a neglected tropical disease caused by the parasite Trypanosoma cruzi. Primarily transmitted by "kissing bugs" (triatomine insects) through their feces during a bite, it can also spread via blood transfusions, oral ingestion, and from mother to baby. Millions worldwide are affected, with about 30% developing severe Chagas cardiomyopathy, a leading cause of heart failure in Latin America. This video explores its transmission routes, symptoms, the growing number of autochthonous cases in the US, and how climate change impacts transmission risk, especially for canine Chagas. Understanding this disease is the crucial first step in tackling this global health challenge.