The Neuro Network

Ep.49 Brain vs. Donut: How Orexin Neurons Push Us to Exercise


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In this episode, we explore how orexin neurons in the brain help us prioritize exercise over tempting distractions like delicious food. Discover the science behind this brain-powered 'gym coach' and learn why some people are better at resisting temptation—giving us fresh insights into motivation, decision-making, and the battle between brain and cravings.

Paper: Tesmer, A. L., Li, X., Bracey, E., Schmandt, C., Polania, R., Peleg-Raibstein, D., & Burdakov, D. (2024). Orexin neurons mediate temptation-resistant voluntary exercise. Nature Neuroscience, 1-9.

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The Neuro NetworkBy Nick Burgraff, PhD