Med x Decode

EP82: Cracking the Feline Cancer Code

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Researchers analyzed 493 feline tumor-normal pairs to map the first comprehensive feline "oncogenome". The study reveals that cats share striking genetic similarities with human cancers, particularly involving the TP53 gene and MYC alterations. These findings are a game-changer for precision oncology in pets, enabling targeted therapies once reserved for humans.



Reference:

  • Francis, B. A., Ludwig, L., He, C., Dobromylskyj, M., Bertram, C. A., Aupperle-Lellbach, H., Wong, H., Foster, A. P., Arends, M. J., Suárez-Bonnet, A., Priestnall, S. L., Tatiersky, L., Castillo-Alcala, F., Rupp, A., Khachadoorian, A., Parlak, E., Inglebert, M., Umamaheswaran, S., Cheema, S., . . . van der Weyden, L. (2026). The oncogenome of the domestic cat. Science, 391(6787). https://doi.org/10.1126/science.ady6651

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