The classic Philadelphia-negative MPNs, which include Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF), are myeloproliferative disorders all characterized by clonal expansion of an abnormal hematopoietic stem/progenitor cell. This leads to excessive production of mature myeloid elements, such as an overabundance of red blood cells in PV or a marked increase in platelets in ET. Although biologically distinct, these disorders share a common predisposition to thrombosis

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