Welcome to Cardiology Today – Recorded January 04, 2026. This episode summarizes 5 key cardiology studies on topics like dendritic cells and allograft tolerance. Key takeaway: Epicardial Cells Regulate Ventricular Compaction.

Article Links:

Article 1: Activation of the Immunoregulatory Cation Channel TMEM176B by a Nitroalkene Derivative of Salicylate Prolongs Graft Survival. (Transplantation)

Article 2: Invasion of Epicardial-Derived Cells to the Trabeculae Mediated by NFPs-Fgf Signaling Regulates Ventricular Compaction. (Circulation. Heart failure)

Article 3: Outcomes of Percutaneous Coronary Intervention for Cardiogenic Shock After Coronary Artery Bypass Graft. (The American journal of cardiology)

Article 4: Impacts of Mitral Annular Calcification on Heart Failure With Preserved Ejection Fraction. (The American journal of cardiology)

Article 5: Mini-Crush Versus Double Kissing Crush in Bifurcation Percutaneous Coronary Intervention: Insights From PROGRESS-BIFURCATION Registry. (The American journal of cardiology)

Full episode page: https://podcast.explainheart.com/podcast/epicardial-cells-regulate-ventricular-compaction-01-04-26/

Journal: Transplantation

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40691833

Summary: Researchers found that transmembrane protein 176B, an intracellular cation channel, is associated with allograft tolerance. The study demonstrated that this protein controls the tolerogenic function of dendritic cells and inhibits the NOD-, LRR-, and pyrin domain-containing protein 3 inflammasome. Activation of transmembrane protein 176B by a nitroalkene derivative of salicylate successfully prolonged graft survival. These findings reveal a mechanism by which transmembrane protein 176B activation contributes to sustained graft survival.

Journal: Circulation. Heart failure

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41477684

Summary: Researchers found that the invasion of epicardial-derived cells into the trabeculae regulates ventricular compaction. This crucial process is mediated by Numb and fibroblast growth factor signaling pathways. These findings establish a fundamental mechanism underlying normal ventricular compaction and provide significant insight into the pathogenesis of left ventricular noncompaction cardiomyopathy. Understanding this pathway offers a clearer picture of this prevalent pediatric cardiomyopathy.

Journal: The American journal of cardiology

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41161558

Summary: This retrospective cohort study conducted a comparative analysis of outcomes for adults experiencing myocardial infarction and cardiogenic shock following coronary artery bypass graft surgery. The study directly compared patients who underwent percutaneous coronary intervention within 24 hours to those who did not. Researchers utilized propensity score matching and Fine-Gray models to derive adjusted and unadjusted hazard ratios and subdistribution hazard ratios for various outcomes. This comprehensive approach established a direct comparison of interventional strategies in this specific, high-risk patient population.

Journal: The American journal of cardiology

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41138985

Summary: A multi-cohort study successfully created and propensity score matched various cohorts to investigate the links between mitral annular calcification and heart failure with preserved ejection fraction. Researchers found that hospitalized patients without prior heart failure, when stratified by the presence or absence of mitral annular calcification, allowed for assessment of the risk of developing heart failure. These studies explored established associations and shared risk factors between mitral annular calcification and heart failure with preserved ejection fraction. This comprehensive analysis provides a foundational dataset for understanding their relationship.

Journal: The American journal of cardiology

PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41138984

Summary: An observational, multicenter study compared procedural characteristics of patients undergoing two-stent bifurcation percutaneous coronary intervention using either the mini-crush or double kissing crush techniques. The study found that an international cohort from the PROGRESS-BIFURCATION registry was assembled for this comparative analysis. This investigation directly compared these two distinct approaches to bifurcation stenting. The findings offer practical insights into the application of these interventional techniques for coronary bifurcation lesions.

Today’s date is January 04, 2026. Welcome to Cardiology Today. Here are the latest research findings.

Article number one. Activation of the Immunoregulatory Cation Channel TMEM176B by a Nitroalkene Derivative of Salicylate Prolongs Graft Survival. Researchers found that transmembrane protein 176B, an intracellular cation channel, is associated with allograft tolerance. The study demonstrated that this protein controls the tolerogenic function of dendritic cells and inhibits the NOD-, LRR-, and pyrin domain-containing protein 3 inflammasome. Activation of transmembrane protein 176B by a nitroalkene derivative of salicylate successfully prolonged graft survival. These findings reveal a mechanism by which transmembrane protein 176B activation contributes to sustained graft survival.

Article number two. Invasion of Epicardial-Derived Cells to the Trabeculae Mediated by NFPs-Fgf Signaling Regulates Ventricular Compaction. Researchers found that the invasion of epicardial-derived cells into the trabeculae regulates ventricular compaction. This crucial process is mediated by Numb and fibroblast growth factor signaling pathways. These findings establish a fundamental mechanism underlying normal ventricular compaction and provide significant insight into the pathogenesis of left ventricular noncompaction cardiomyopathy. Understanding this pathway offers a clearer picture of this prevalent pediatric cardiomyopathy.

Article number three. Outcomes of Percutaneous Coronary Intervention for Cardiogenic Shock After Coronary Artery Bypass Graft. This retrospective cohort study conducted a comparative analysis of outcomes for adults experiencing myocardial infarction and cardiogenic shock following coronary artery bypass graft surgery. The study directly compared patients who underwent percutaneous coronary intervention within 24 hours to those who did not. Researchers utilized propensity score matching and Fine-Gray models to derive adjusted and unadjusted hazard ratios and subdistribution hazard ratios for various outcomes. This comprehensive approach established a direct comparison of interventional strategies in this specific, high-risk patient population.

Article number four. Impacts of Mitral Annular Calcification on Heart Failure With Preserved Ejection Fraction. A multi-cohort study successfully created and propensity score matched various cohorts to investigate the links between mitral annular calcification and heart failure with preserved ejection fraction. Researchers found that hospitalized patients without prior heart failure, when stratified by the presence or absence of mitral annular calcification, allowed for assessment of the risk of developing heart failure. These studies explored established associations and shared risk factors between mitral annular calcification and heart failure with preserved ejection fraction. This comprehensive analysis provides a foundational dataset for understanding their relationship.

Article number five. Mini-Crush Versus Double Kissing Crush in Bifurcation Percutaneous Coronary Intervention: Insights From PROGRESS-BIFURCATION Registry. An observational, multicenter study compared procedural characteristics of patients undergoing two-stent bifurcation percutaneous coronary intervention using either the mini-crush or double kissing crush techniques. The study found that an international cohort from the PROGRESS-BIFURCATION registry was assembled for this comparative analysis. This investigation directly compared these two distinct approaches to bifurcation stenting. The findings offer practical insights into the application of these interventional techniques for coronary bifurcation lesions.

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dendritic cells, allograft tolerance, TMEM176B, cardiogenic shock, Left ventricular noncompaction cardiomyopathy, hazard ratio, Mini-crush technique, coronary stenting, inflammasome, Fgf signaling, double kissing crush technique, cardiac calcification, epicardial-derived cells, Mitral annular calcification, Numb, bifurcation percutaneous coronary intervention, ventricular compaction, graft survival, Myocardial infarction, risk assessment, percutaneous coronary intervention, heart failure with preserved ejection fraction, coronary artery bypass graft.

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