Inside Matters

Episode 003 - Dr Morgan Langille – microbiome bioinformatics, DNA sequencing, metagenomics

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Dr Morgan Langille, an expert in bioinformatics, talks about developing novel technologies and techniques that enable a better understanding of human-microbial interactions. 
 
Dr Langille discusses advances in the microbiome field as well as combining computer science and microbiology to lead to new therapeutics and diagnostics.
 
Episode Time Stamps
  • 00:00 Intro
  • 00:30, How Dr Langille got into the field of the microbiome
  • 04:30, Gene duplication and reverse transcription
  • 05:48, What is bioinformatics?
  • 06:34, The evolution of bioinformatics 
  • 09:30, Genomic islands
  • 1:04 - Phages
  • 14:30 Dr Langille’s first bioinformatics tool 
  • 16:00 Bacterial genome libraries 
  • 18:20 Extremeophilic bacteria
  • 19:00 Will there be bugs in space
  • 21:42 Bacteria on Mars 
  • 22:15 Human microbiome diversity 
  • 23:30 Number of human cells vs microbes in the body 
  • 25:00 Genomic diversity within the microbiome 
  • 28:00 Perfect bioinformatics 
  • 33:40 Bioinformatics and microbiome research
  • 34:37 Short read vs long read sequencing 
  • 45:30 Shotgun metagenomics 
  • 48:00 Bioinformatic tool development 
  • 1:01:00 Differences in bioinformatic tools and impact on research 
  • 1:06:00 Solutions to current technology challenges in bioinformatics
  • 1:10:06 Tools that Morgan has developed 
  • 1:08:05 PICRUSt - bioinformatic tool 
  • 1:18:35 Jarvis - bioinformatic tool 
  • 1:24:00 Talent wars for bioinformatics 
  • 1:26:36 Machine learning and AI
  • 1:32:51 Colorectal cancer and AI 
  • 1:36:35 Is blood sterile?
  • 1:38:00 What does the future of medicine look like 
  • 1:40:51 DIY FMT

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    Inside MattersBy Dr James McIlroy