In this episode of MedEd Insider, we tackle one of the most critical and challenging presentations in the emergency room: chest pain. Guided by the latest evidence from Rosen’s Emergency Medicine and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain, we dive deep into a structured approach to assessing patients with chest pain. We’ll explore how to differentiate between life-threatening and less urgent causes, key elements of history-taking, essential physical exam findings, and the appropriate use of diagnostic tools. By the end of this episode, you’ll gain practical insights and a step-by-step strategy to confidently and efficiently manage chest pain in the ER.