Today we unpack one of the most overlooked tools for gut and immune resilience: ImmunoLin®—a serum-derived bovine immunoglobulin (SBI) rich in IgG that acts like a “catcher’s mitt” for inflammatory antigens in the gut. Brandon talks with Brian Kaufman (VP, Proliant Health & Biologicals) about how antibodies bind LPS and other microbial fragments, lower antigen load at the gut lining, and help the immune system stop “overreacting” and start resolving. We cover real-world dosing (mild→severe), how long to run a protocol (why ~6 weeks matters), what to stack it with (butyrate, prebiotic fiber, glutamine, enzymes), and who should not take it (true beef allergy). We also discuss clinical signals—like fewer symptomatic days with bloating, pain, diarrhea, and brain fog—and why under-dosed formulas fail.

In this episode

What SBI/IgG actually does (the catcher’s mitt mechanism) and why that calms the gut–immune loop

• Trials discussed: fewer symptomatic days in IBS; high-fat challenge with LPS stability after 8 weeks at 1–2 g/day
• Dosing by severity: mild–moderate (start 2 g/day × 10 days → 1 g/day), severe (5–10 g/day × 10 days → taper), run ~6 weeks (gut turnover ≈ 21+ days)
• Stacking strategy: ImmunoLin® first (“weed”), then feed—butyrate (e.g., BIOMEnd®), prebiotic fiber (Sunfiber®/Solnul®), glutamine, broad enzyme, then probiotics
• Everyday wins: fewer “bathroom-map” moments, steadier afternoons, clearer skin via the gut–skin axis
• Contraindication: true beef allergy
• Formulation talk: flavor/odor advantages vs. many butyrates; why dose matters (match clinical ranges)

Take the free Drift Quiz — https://www.themetaboliccompass.com/quiz

Explore the podcast — https://www.themetaboliccompass.com/listen