In this, our inaugural episode, we explore common mechanisms underlying acute hypoxemic and hypercapneic respiratory failure. Concepts discussed include the oxygen delivery equation, differentiating hypoxia from hypoxemia, and a discussion of V/Q mismatch and shunts. In the follow-up episode - Acute Respiratory Failure II: Clinical Management & Oxygen Therapies - we'll apply these concepts to the management of acute respiratory failure and discuss the benefits and harms of oxygen therapy. 

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