This episode focuses on how the body responds to combined weather stressors, such as heat with humidity or cold with wind. We detail the integration of the nervous, cardiovascular, respiratory, and endocrine systems to maintain homeostasis under extreme conditions. Case studies illustrate responses to challenging scenarios like exercising in a hot, humid environment or climbing in a cold, windy climate. We also compare physiological adaptations to tropical versus Arctic conditions and emphasize the importance of preparation and acclimatization. Future episodes will dive deeper into heat stress, including acute and chronic responses and heat illnesses.