In this Breaking News #HRStv episode focused on LAAO 2025, host Daniel Alyesh, MD, FHRS is joined by John M. Mandrola, MD, and Luigi Di Biase, MD, PhD, FHRS to explore the evolving evidence behind left atrial appendage occlusion (LAAO). The experts review key clinical trials—including PROTECT, PREVAIL, and OPTION—alongside insights from the NCDR registry, weighing the data on both efficacy and safety. Presented in a debate-style format, this engaging discussion concludes with a forward-looking preview of the highly anticipated CHAMPION-AF trial, set to be presented at ACC 2026.

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