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You know them by their brand names, like Ozempic, Trulicity, or Mounjaro. They're the GLP-1 receptor agonists that were originally formulated for Type 2 diabetes but have caused a revolution in the treatment of weight loss. As more research rolls in, they’re also looking like game-changers for treating conditions as far-ranging as heart disease, dementia, and substance use disorders. Do they represent a medical breakthrough on the level of penicillin, or are they too good to be true? Joe and Mark review the pros and cons and consider how some things in life can be truly double-edged swords. (Recorded February 28, 2025.)