It’s time for another new series, this time focusing on Sickle Cell Disease! In this first episode, we lay the foundation for our future discussions. This episode can be dense, but rest assured we will revisit these concepts and expand on them throughout the series.

Contents:

- What is hemoglobin?

- What is the underlying problem in sickle cell disease genotypically?

- Why is the presence of sickled cells problematic?

- What is sickle cell trait?

- What are other presentations similar to sickle cell disease/HbSS?

- What are common electrophoresis patterns?

- What is "hereditary persistence of hemoglobin"?

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