Episode 12 focuses on the body’s immediate responses to acute heat stress, triggered by high temperatures, physical exertion, or inadequate cooling mechanisms. We delve into the roles of the nervous, cardiovascular, respiratory, and endocrine systems in thermoregulation. Key topics include the importance of sweating and vasodilation, the impact of fluid loss and dehydration, and the hormonal adjustments required to maintain balance. Real-world examples illustrate the challenges faced by workers, athletes, and vulnerable populations during heat stress.