This month we are joined by Dr Joshua Lang, from the University of Wisconsin Carbone Comprehensive Cancer Center, Madison, who will present on the very current topic of ‘Metastatic Niche and Treatment Resistanc’. We will also hear from Prof Andrea Alimonti, from the Institute of Oncology Research, Bellinzona, who will help to add clarity around the fascinating topic of ‘Role of Microbiome in Treatment Resistance’. It is co-chaired by Dr Gerhardt Attard, from University College London, who leads the group disucssion to close the episode.