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Psychoactive substances have been ingested by human beings for millennia. But for a few decades at the end of the 20th century, many were banned in the U.S. as part of a cultural backlash manifesting itself in the disastrous War on Drugs. Now that’s slowly changing, as the medical industrial complex reconsiders the use of psychedelic drugs like MDMA, psilocybin, and LSD for treating depression, anxiety, PTSD, substance use disorders, and much more. Joe and Mark discuss the history of psychedelics, their therapeutic use in psychotherapy, and why they might be game changers for the many people for whom existing treatments and medications just don’t work. (Taping date: December 5, 2025.)