In this insightful interview, Dr Marty Leon shares his experience in transcatheter aortic-valve implantation (TAVI) with interventional fellow Dr Philippe Genereux. The discussion addresses the pioneering work of Drs Alain Cribier and John Webb, Dr Leon's involvement in the field, important clinical trials such as PARTNER, and lessons learned from the 10 000 procedures performed so far. They also review devices and techniques and ponder the future of TAVI, including insight into collaboration across multiple disciplines to create the ideal heart-valve therapy center.