A more in-depth look at the lives of Georg Peuerbach, Johannes de Regio Monte (aka, Johanes Muller, aka Regiomontanus) and Cardinal Basilios Bessarion with a specific focus on the years between 1454 and 1476. The development of the Epitome of the Almagest is discussed as is the role of astrology in late medieval and early modern culture, specifically in relation to the practice of medicine.