On November 6, 2025, I spoke with Dr. Jason O'Connor about the behavioral and psychological effects of inflammation, and their similarity to depression. Jason explained how inflammation can produce those symptoms by increasing levels of kynurenine and metabolites in the brain. We discussed the possibility that depression may sometimes result from a rise in those metabolites in the absence of inflammation.

Guest:

Jason O'Connor, Associate Professor of Pharmacology at the UT San Antonio Long School of Medicine and the Audie Murphy VA Hospital.

Host:

Charles Wilson, Department of Neuroscience, Developmental and Regenerative Biology, UT San Antonio

Thanks to James Tepper for original music