After Will Smith's infamous slapping of Chris Rock over a joke about his wife's Alopecia, the guys got to wondering: what diseases are truly the worst of the worst.  

With the idea of, what Charitable causes most deserve donations, the guys set up a Double-Elimination bracket of the worst ailments and diseases to narrow down - in their own, definitely not a Doctor, opinions - which disease or ailment is most severe.  

Join the guys this week as they pit 16 of the worst diseases to find out what takes the cake as the most formidable disease and most worthy of charitable donations.