In this episode, we sit down with Dr. Elizabeth Laughlin, PharmD, to explore the use of Leucovorin, a prescription form of folate, and its emerging role in supporting children with certain neurological and folate-related immune conditions. Dr. Laughlin breaks down how Leucovorin works in the body, including its ability to act as a “master key” that helps folate cross critical barriers in the brain.

The conversation dives into the current research surrounding cerebral folate deficiency, why some children may respond differently to treatment, and how side effects such as hyperactivity or irritability can sometimes be misunderstood. Dr. Laughlin also discusses important drug interactions, particularly with anti-epileptic medications, and why careful monitoring and collaboration with healthcare providers is essential.

We also talk about advocacy, empowering parents with knowledge, and how to have productive, goal-oriented conversations with medical teams. Looking ahead, Dr. Laughlin shares insight into how genetic testing and personalized medicine may shape the future of Leucovorin use and other targeted therapies.

Subjects covered include:

• What Leucovorin is and how it differs from other forms of folate

• How Leucovorin supports folate transport in the brain

• Current research on cerebral folate deficiency and neurological conditions

• Common side effects and how to interpret them

• Drug interactions and safety considerations

• The importance of parent advocacy and clear communication with providers

• Long-term use, monitoring, and realistic expectations

• The future of genetic testing and personalized treatment approaches

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