In this episode, we explore the long-term physiological effects of microgravity, focusing on the musculoskeletal, cardiovascular, and vestibular systems, as well as cognitive and psychological challenges. We discuss bone loss, muscle atrophy, reduced VO₂ max, and how the vestibular system malfunctions in space. The episode also touches on the impact of disrupted circadian rhythms, sensory overload, and emotional strain during long-duration missions.