Undifferentiated Pleomorphic Sarcomas are one of the most common sarcomas. This class of tumors are aggressive with a risk of local recurrence and distant metastasis. We discuss the presentation, diagnostic challenges, and management of these sarcomas.

Bennett C, Bharadwaj S, Arndt A, Chawla A. A systematic review of undifferentiated pleomorphic sarcoma of the chest wall. Chin Clin Oncol. 2023 Dec;12(6):66.

Lesovaya EA, Fetisov TI, Bokhyan BY, Senchenko MA, Rogozhin DV, Maksimova VP, Demko AN, Belitsky GA, Yakubovskaya MG, Kirsanov KI. Genetic Heterogeneity of Undifferentiated Pleomorphic Sarcoma: Is There Potential for Targeted Therapy? Cancers (Basel). 2025 Nov 10;17(22):3613

Sun H, Liu J, Hu F, Xu M, Leng A, Jiang F, Chen K. Current research and management of undifferentiated pleomorphic sarcoma/myofibrosarcoma. Front Genet. 2023 Feb 16;14:1109491

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