The Nextflow Podcast

Episode 44: Regulatory revolution - Open source software in pharma and clinical settings.

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In episode 44 of the Nextflow Channels podcast, Phil Ewels welcomes Alex Pelzer— a key figure in the Nextflow and nf-core community. Alex shares his journey from academia to the pharmaceutical industry, highlighting the critical role of regulatory frameworks in bioinformatics.

🌟 Key Highlights:

  • The transition from working at QBiC to Boehringer Ingelheim.
  • The importance of maintaining high-quality, reproducible pipelines in bioinformatics.
  • Understanding regulatory requirements and their impact on clinical trials.
  • How regulatory standards and open-source initiatives like @nf-core are shaping the future of bioinformatics.

    • Alex also discusses the formation of the @nf-core Regulatory Special Interest Group, which aims to bring together experts in the field to establish and promote best practices for ensuring pipeline quality and compliance with regulatory standards.

    Looking forward to seeing many of you at the upcoming #NextflowSummit in Barcelona this October! We’ll be working with this #regulatory group during the nf-core hackathon.

    00:00 Episode 44: Regulatory revolution

    00:06 Introductions
    00:33 Upcoming Nextflow Summit Announcement
    01:34 Alex’s Background and Early Days with Nextflow
    04:41 Formation and Growth of nf-core
    06:18 Transition to Pharma and Regulatory Work
    08:56 Regulatory Challenges and Practices in Bioinformatics
    13:30 Tool Selection and Quality Assurance
    15:23 Evaluating Software Trustworthiness
    17:08 Overhead in Academia vs. Industry
    18:11 Downstream analysis
    20:57 Regulatory Special Interest Group
    25:28 Special Interest Groups in nf-core
    28:59 Future Directions and Community Involvement
    30:15 Open source contributions in pharma
    33:27 Conclusion and Upcoming Events

    ...more
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