Isaac and Jeffrey discuss falsehoods that programmers believe about projects. They explore the misconception that the project will solve the stated problem, highlighting instances where the delivered software did not actually solve the problem. They also discuss the importance of understanding how the user will use the software and the need for clear communication and feedback loops to ensure that the project is on track. They emphasize that the success of a project is not solely determined by the software, but also by factors such as the alignment of project goals and the availability of resources. Overall, they highlight the need for critical thinking and continuous communication to avoid common pitfalls in project development.