In this episode of History’s Horrible Humans, we explore the life and crimes of Samuel Little, the man the FBI calls America’s most prolific serial killer. From his troubled childhood and decades of petty crime to his horrifying spree of strangulations across 19 states, Little’s story reveals the failures of a justice system that overlooked society’s most vulnerable. We trace his capture through DNA evidence, his shocking confessions, and the haunting sketches that gave voice to dozens of forgotten victims. It’s a chilling look into how one man evaded justice for decades - and how the truth finally caught up to him.