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Episode 6 – Blood Types
In this week’s episode I’m talking about blood types, and a technique that could be used to develop universal blood:
https://ia601505.us.archive.org/5/items/WABEpisode6/WABEpisode6.mp3
Here’s a good visual representation of the red blood cells of different ABO blood types, and the antibodies present in plasma associated with these types.
This image allows you to visualize the sugar structures on the different blood type red blood cells. Each hexagon represents a different sugar type. Note how to A, B, and AB red blood cells have additional sugars that the O red blood cells do not. These are the desired targets of the enzymes.
As promised here’s the link to the abstract I discuss:
Discovery of CAZYmes for cell surface glycan removal through metagenomics: Towards universal blood
And here is an additional paper by the same group:
oward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution
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By Andrea Bedford
5
22 ratings
In this week’s episode I’m talking about blood types, and a technique that could be used to develop universal blood:
https://ia601505.us.archive.org/5/items/WABEpisode6/WABEpisode6.mp3
Here’s a good visual representation of the red blood cells of different ABO blood types, and the antibodies present in plasma associated with these types.
This image allows you to visualize the sugar structures on the different blood type red blood cells. Each hexagon represents a different sugar type. Note how to A, B, and AB red blood cells have additional sugars that the O red blood cells do not. These are the desired targets of the enzymes.
As promised here’s the link to the abstract I discuss:
Discovery of CAZYmes for cell surface glycan removal through metagenomics: Towards universal blood
And here is an additional paper by the same group:
oward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution