In this episode of the Strive Podcast, I am excited to host Dr. Patrick Brennan, the Chief Medical Officer of the University of Pennsylvania Health System (UPHS). Dr. Brennan, who began his career as an infectious disease specialist, now plays a pivotal role in managing clinical leadership and ensuring operational excellence at UPHS. Our conversation covers a wide range of topics, including his journey from a specialist to a leading healthcare executive, his strategies for maintaining high safety standards and operational efficiency, and his approach to determining best practices in patient care. We delve into the challenges he faced and discuss how these experiences have shaped UPHS's operations. Dr. Brennan also shares his insights on the integration of cutting-edge technologies and his enthusiasm for future technological advancements. Moreover, we discuss his strategies for enhancing patient safety and his views on value-based care and its impact on population health management.