In this episode of MedPOD AFMC, Brig (Dr) J Muthukrishnan sits down with Air Cmde (Dr) Aditya Sapra, Professor and Head of the Department of Anaesthesiology at AFMC, Pune, to explore the essential aspects of mechanical ventilation. The discussion delves into the physiological basis of ventilation, common indications, various modes, and the principles of patient care during mechanical support. This episode serves as a foundational guide for medical students and clinicians, providing practical insights into managing patients requiring ventilatory assistance.