This month we are joined by Dr Russell Pachynski, from Washington University, St Louis, who answers 'Do Bispecific Immunotherapies Have a Future?'. We will also hear from Prof Ana Aparicio, from MD Anderson Cancer Center, Houston, Texas, who will present her thoughts on the question 'What are Promising Treatment Approaches for Aggressive Variant / Neuroendocrine Prostate Cancer?'. It is co-chaired by Dr Sumit Subudhi, from MD Anderson Cancer Center, Houston, Texas, who leads the group disucssion to close the episode.